学术报告首页>学术报告

中科院计算生物学重点实验室学术报告:CTCF is a critical player in controlling gene expression noise

副标题:

时间:2017-09-28  来源:文本大小:【 |  | 】  【打印

Speaker: Keji Zhao, PhD
                Director and Senior Investigator, Systems Biology Center,
                National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)

                Web: https://www.nhlbi.nih.gov/research/intramural/researchers/pi/zhao-keji/

Time : 1:30-4:00 pm , Oct. 10(Tuesday)
Venue: Room 300, SIBS Main Building, Yueyang Road 320
Host:Prof. Gang Wei
           CAS-MPG Partner Institute for Computational Biology

Title: CTCF is a critical player in controlling gene expression noise


Abstract:

    Recent studies indicate that even a homogeneous population of cells exhibit substantial cell-to-cell variation in gene expression. Our previous single-cell DNase-seq analysis suggests that chromatin states underlie the gene expression heterogeneity across different cells. CTCF is a key protein in chromatin organization in mammalian cells. I will present data to show that the enhancer-promoter interaction mediated by CTCF plays a critical role in controlling gene expression and reducing cell-to-cell variation of expression.

 

Bio:

    Dr. Zhao’s research focuses on the epigenetic regulation of chromatin. Understanding how epigenetic patterns are established during development and how improper epigenetic signals contribute to disease is the long-term goal for his lab. His lab developed the ChIP-SAGE, ChIP-Seq, MNase-Seq, and scDNase-seq techniques and also developed corresponding algorithms to analyze these data. Using these approaches, Dr. Zhao’s lab has been pioneering whole-genome analyses of chromatin modifications in higher eukaryotic systems. By identifying these genome-wide epigenetic patterns, Dr. Zhao’s research has revealed numerous insights into the relationship between the epigenome, chromatin-modifying enzymes, and gene expression.

    All are welcome!

相关附件
相关文档
2014 中国科学院上海生命科学研究院 版权所有
地址:上海岳阳路012号 邮编:200031 电话:0185545 传真:58-512555
电子信箱:sibc.ac.cn@yahu.cn